Pelvic Masses Can Be Ovarian Cancer

OVA1plus has the highest risk detection for all ages, ethnicities, stages and all types of ovarian cancer.

What is a pelvic mass?

A pelvic mass, also known as an ovarian or adnexal mass, is a tissue mass in the adnexa of the uterus, which refers to the space occupied by the uterus, ovaries and fallopian tubes. Ovarian masses can be a risk factor for ovarian cancer, however, most masses are often not cancer and go away on their own without treatment within a few
menstrual cycles.

Graphic of a woman's pelvis showing the adnexal of the uterus, fallopian tubes, ovaries and uterus.

In premenopausal women, most adnexal masses are caused by:

  • Ectopic pregnancy
  • Ovarian adnexal cysts
  • Tumors
  • Polycystic ovaries and abscesses

After menopause, more likely causes include fibroid tumors, fibromas, and malignant tumors.


The majority of ovarian masses are benign, but a diagnosis is difficult because there are many forms it can take. In fact, most are asymptomatic and are discovered during a routine pelvic or other examination rather than because they cause pain or discomfort.


Most ovarian cysts develop, shrink, and disappear within the course of a single menstruation cycle. In some cases, however, they grow larger and remain in the ovary, fallopian tube, or uterus. An ovarian adnexal mass must be carefully evaluated using information obtained from a physician’s exam, imaging/ultrasound, and appropriate blood testing for ovarian cancer.

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OVA1plus is a reflex process which performs OVA1 and OVERA, both FDA-cleared tests for women with adnexal masses. OVA1plus helps you further stratify your patient’s risk of malignancy for women with pelvic masses planned for surgery. Benefits of this enhanced test offering include; Reducing the falsely elevated rate by up to 50%, maintaining the high rate of detection (sensitivity) for ovarian cancer risk, continuing to provide confidence in low-risk results with a high negative predictive value, and increased specificity by up to 20%.

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